Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse

A significant barrier to the successful general development of small-interfering RNA (siRNA) therapeutics is the ability to deliver them systemically to target organs and cell types. In this study, we have developed a mouse strain that will facilitate the evaluation of the efficacy of siRNA delivery...

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Bibliografiske detaljer
Main Authors: Svensson, Robert U, Shey, Michael R, Ballas, Zuhair K, Dorkin, J Robert, Goldberg, Michael, Akinc, Akin, Langer, Robert, Anderson, Daniel G, Bumcrot, David, Henry, Michael D
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014086/
https://ncbi.nlm.nih.gov/pubmed/18781145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.187
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