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Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis

Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. Previous in vitro studies have indicated that CLDN3 overexpression promotes the migration, invasion, and survival of ovarian cancer cells. Here, we investigated the efficacy of lipidoid-formulated CLDN3 siR...

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Bibliografski detalji
Glavni autori: Huang, Yu-Hung, Bao, Yunhua, Peng, Weidan, Goldberg, Michael, Love, Kevin, Bumcrot, David A., Cole, Geoffrey, Langer, Robert, Anderson, Daniel G., Sawicki, Janet A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651300/
https://ncbi.nlm.nih.gov/pubmed/19208807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813348106
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