KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain

Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5–S6) is surrounded by four voltage sensor domains (S1–S4). One key question remains: how do voltage sensors (S4) regulate pore gating? P...

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Detalhes bibliográficos
Main Authors: Choveau, Frank S., Rodriguez, Nicolas, Ali, Fayal Abderemane, Labro, Alain J., Rose, Thierry, Dahimène, Shehrazade, Boudin, Hélène, Le Hénaff, Carole, Escande, Denis, Snyders, Dirk J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013029/
https://ncbi.nlm.nih.gov/pubmed/20940310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146324
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