KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain

Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5–S6) is surrounded by four voltage sensor domains (S1–S4). One key question remains: how do voltage sensors (S4) regulate pore gating? P...

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Bibliografische gegevens
Hoofdauteurs: Choveau, Frank S., Rodriguez, Nicolas, Ali, Fayal Abderemane, Labro, Alain J., Rose, Thierry, Dahimène, Shehrazade, Boudin, Hélène, Le Hénaff, Carole, Escande, Denis, Snyders, Dirk J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013029/
https://ncbi.nlm.nih.gov/pubmed/20940310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146324
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