KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain

Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5–S6) is surrounded by four voltage sensor domains (S1–S4). One key question remains: how do voltage sensors (S4) regulate pore gating? P...

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Bibliografiske detaljer
Main Authors: Choveau, Frank S., Rodriguez, Nicolas, Ali, Fayal Abderemane, Labro, Alain J., Rose, Thierry, Dahimène, Shehrazade, Boudin, Hélène, Le Hénaff, Carole, Escande, Denis, Snyders, Dirk J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013029/
https://ncbi.nlm.nih.gov/pubmed/20940310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146324
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