KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain

Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5–S6) is surrounded by four voltage sensor domains (S1–S4). One key question remains: how do voltage sensors (S4) regulate pore gating? P...

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Main Authors: Choveau, Frank S., Rodriguez, Nicolas, Ali, Fayal Abderemane, Labro, Alain J., Rose, Thierry, Dahimène, Shehrazade, Boudin, Hélène, Le Hénaff, Carole, Escande, Denis, Snyders, Dirk J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013029/
https://ncbi.nlm.nih.gov/pubmed/20940310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146324
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