Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Damage to mitochondria can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. However, fusion of uncoupled mitochondria with polarized mitochondria can compensate for damage, reverse membrane depolarizatio...

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Bibliographic Details
Main Authors: Tanaka, Atsushi, Cleland, Megan M., Xu, Shan, Narendra, Derek P., Suen, Der-Fen, Karbowski, Mariusz, Youle, Richard J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010068/
https://ncbi.nlm.nih.gov/pubmed/21173115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007013
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