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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron maintenance is unknown, recent work has linked Parkin to the regulation of mitochondria. Its loss is associated...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2592826/ https://ncbi.nlm.nih.gov/pubmed/19029340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200809125 |
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