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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811155/ https://ncbi.nlm.nih.gov/pubmed/20126261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000298 |
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