PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...

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Bibliografiske detaljer
Main Authors: Narendra, Derek P., Jin, Seok Min, Tanaka, Atsushi, Suen, Der-Fen, Gautier, Clement A., Shen, Jie, Cookson, Mark R., Youle, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811155/
https://ncbi.nlm.nih.gov/pubmed/20126261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000298
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