PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...

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Bibliografske podrobnosti
Main Authors: Narendra, Derek P., Jin, Seok Min, Tanaka, Atsushi, Suen, Der-Fen, Gautier, Clement A., Shen, Jie, Cookson, Mark R., Youle, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811155/
https://ncbi.nlm.nih.gov/pubmed/20126261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000298
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