PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we...

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Autors principals: Narendra, Derek P., Jin, Seok Min, Tanaka, Atsushi, Suen, Der-Fen, Gautier, Clement A., Shen, Jie, Cookson, Mark R., Youle, Richard J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811155/
https://ncbi.nlm.nih.gov/pubmed/20126261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000298
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