Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

Mitochondrial homeostasis via mitochondrial dynamics and quality control is crucial to normal cellular functions. Mitophagy (mitochondria removed by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), requires Parkin, but it is not clear why Parkin is...

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Main Authors: Ding, Wen-Xing, Guo, Fengli, Ni, Hong-Min, Bockus, Abigail, Manley, Sharon, Stolz, Donna B., Eskelinen, Eeva-Liisa, Jaeschke, Hartmut, Yin, Xiao-Ming
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516781/
https://ncbi.nlm.nih.gov/pubmed/23095748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413682
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