Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

Mitochondrial homeostasis via mitochondrial dynamics and quality control is crucial to normal cellular functions. Mitophagy (mitochondria removed by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), requires Parkin, but it is not clear why Parkin is...

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Dettagli Bibliografici
Autori principali: Ding, Wen-Xing, Guo, Fengli, Ni, Hong-Min, Bockus, Abigail, Manley, Sharon, Stolz, Donna B., Eskelinen, Eeva-Liisa, Jaeschke, Hartmut, Yin, Xiao-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516781/
https://ncbi.nlm.nih.gov/pubmed/23095748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413682
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