Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

Mitochondrial homeostasis via mitochondrial dynamics and quality control is crucial to normal cellular functions. Mitophagy (mitochondria removed by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), requires Parkin, but it is not clear why Parkin is...

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Bibliografiska uppgifter
Huvudupphovsmän: Ding, Wen-Xing, Guo, Fengli, Ni, Hong-Min, Bockus, Abigail, Manley, Sharon, Stolz, Donna B., Eskelinen, Eeva-Liisa, Jaeschke, Hartmut, Yin, Xiao-Ming
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516781/
https://ncbi.nlm.nih.gov/pubmed/23095748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413682
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