Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

Mitochondrial homeostasis via mitochondrial dynamics and quality control is crucial to normal cellular functions. Mitophagy (mitochondria removed by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), requires Parkin, but it is not clear why Parkin is...

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Bibliografiske detaljer
Main Authors: Ding, Wen-Xing, Guo, Fengli, Ni, Hong-Min, Bockus, Abigail, Manley, Sharon, Stolz, Donna B., Eskelinen, Eeva-Liisa, Jaeschke, Hartmut, Yin, Xiao-Ming
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516781/
https://ncbi.nlm.nih.gov/pubmed/23095748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413682
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