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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and PINK1 genes are a cause of familial PD. PINK1 is a putative kinase associated with mitochondria, and loss of PINK1 expression leads to mitoc...

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Bibliografiske detaljer
Main Authors: Gegg, Matthew E., Cooper, J. Mark, Chau, Kai-Yin, Rojo, Manuel, Schapira, Anthony H.V., Taanman, Jan-Willem
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583518/
https://ncbi.nlm.nih.gov/pubmed/20871098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq419
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