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Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy. Here, we investigated the impact of mutati...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050809/ https://ncbi.nlm.nih.gov/pubmed/21408142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016746 |
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