Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts

BACKGROUND: Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory chain function and mitochondrial dynamics. More recent publications also described...

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Detalhes bibliográficos
Main Authors: Grünewald, Anne, Voges, Lisa, Rakovic, Aleksandar, Kasten, Meike, Vandebona, Himesha, Hemmelmann, Claudia, Lohmann, Katja, Orolicki, Slobodanka, Ramirez, Alfredo, Schapira, Anthony H. V., Pramstaller, Peter P., Sue, Carolyn M., Klein, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946349/
https://ncbi.nlm.nih.gov/pubmed/20885945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012962
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