SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila

Mutations in the Parkin gene (PARK2) have been linked to a recessive form of Parkinson’s disease (PD) characterized by the loss of dopaminergic neurons in the substantia nigra. Deficiencies of mitochondrial respiratory chain complex I activity have been observed in the substantia nigra of PD patient...

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Publicat a:Hum Mol Genet
Autors principals: Zanon, Alessandra, Kalvakuri, Sreehari, Rakovic, Aleksandar, Foco, Luisa, Guida, Marianna, Schwienbacher, Christine, Serafin, Alice, Rudolph, Franziska, Trilck, Michaela, Grünewald, Anne, Stanslowsky, Nancy, Wegner, Florian, Giorgio, Valentina, Lavdas, Alexandros A., Bodmer, Rolf, Pramstaller, Peter P., Klein, Christine, Hicks, Andrew A., Pichler, Irene, Seibler, Philip
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192413/
https://ncbi.nlm.nih.gov/pubmed/28379402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx132
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