Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells

Mutations in the PRKN gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson’s disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through different cellular pathways, as it protects dopaminergic neu...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Guida, Marianna, Zanon, Alessandra, Montibeller, Luigi, Lavdas, Alexandros A., Ladurner, Judith, Pischedda, Francesca, Rakovic, Aleksandar, Domingues, Francisco S., Piccoli, Giovanni, Klein, Christine, Pramstaller, Peter P., Hicks, Andrew A., Pichler, Irene
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386878/
https://ncbi.nlm.nih.gov/pubmed/30754623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030748
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