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Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells

Mutations in the PRKN gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson’s disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through different cellular pathways, as it protects dopaminergic neu...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Guida, Marianna, Zanon, Alessandra, Montibeller, Luigi, Lavdas, Alexandros A., Ladurner, Judith, Pischedda, Francesca, Rakovic, Aleksandar, Domingues, Francisco S., Piccoli, Giovanni, Klein, Christine, Pramstaller, Peter P., Hicks, Andrew A., Pichler, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386878/
https://ncbi.nlm.nih.gov/pubmed/30754623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030748
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