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A hot oxidant, 3-NO(2)Y(122) radical, unmasks conformational gating in ribonucleotide reductase
Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides and requires a diferric-tyrosyl radical (Y•) cofactor to initiate catalysis. The initiation process requires long range proton-coupled electron transfer (PCET) over 35 Å betw...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005585/ https://ncbi.nlm.nih.gov/pubmed/20929229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1069344 |
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