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Site-specific incorporation of 3-nitrotyrosine as a probe of pK(a) perturbation of redox-active tyrosines in ribonucleotide reductase
E. coli ribonucleotide reductase catalyzes the reduction of nucleoside 5′-diphosphates into 2′-deoxynucleotides and is composed of two subunits: α2 and β2. During turnover, a stable tyrosyl radical (Y·) at Y(122)-β2 reversibly oxidizes C(439) in the active site of α2. This radical propagation step i...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905227/ https://ncbi.nlm.nih.gov/pubmed/20518462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101097p |
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