PECAM-targeted delivery of SOD inhibits endothelial inflammatory response

Elevated generation of reactive oxygen species (ROS) by endothelial enzymes, including NADPH-oxidase, is implicated in vascular oxidative stress and endothelial proinflammatory activation involving exposure of vascular cell adhesion molecule-1 (VCAM-1). Catalase and superoxide dismutase (SOD) conjug...

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Main Authors: Shuvaev, Vladimir V., Han, Jingyan, Yu, Kevin J., Huang, Shaohui, Hawkins, Brian J., Madesh, Muniswamy, Nakada, Marian, Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005426/
https://ncbi.nlm.nih.gov/pubmed/20876216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-169789
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