Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo

Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe conditions including stroke, infarction and sepsis. We have recently reported that superoxide dismutase (SOD) conjugated with antibodies (Ab/SOD) that provide targeted delivery into endothelial endosomes miti...

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Detalhes bibliográficos
Main Authors: Shuvaev, Vladimir V., Han, Jingyan, Tliba, Samira, Arguiri, Evguenia, Christofidou-Solomidou, Melpo, Ramirez, Servio H., Dykstra, Holly, Persidsky, Yuri, Atochin, Dmitriy N., Huang, Paul L., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795626/
https://ncbi.nlm.nih.gov/pubmed/24146950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077002
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