Size and Targeting to PECAM vs ICAM Control Endothelial Delivery, Internalization and Protective Effect of Multimolecular SOD Conjugates

Controlled endothelial delivery of SOD may alleviate abnormal local surplus of superoxide involved in ischemia-reperfusion, inflammation and other disease conditions. Targeting SOD to endothelial surface vs. intracellular compartments is desirable to prevent pathological effects of external vs. endo...

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Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Shuvaev, Vladimir V., Muro, Silvia, Arguiri, Evguenia, Khoshnejad, Makan, Tliba, Samira, Christofidou-Solomidou, Melpo, Muzykantov, Vladimir R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916012/
https://ncbi.nlm.nih.gov/pubmed/27210108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.05.040
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