Size and Targeting to PECAM vs ICAM Control Endothelial Delivery, Internalization and Protective Effect of Multimolecular SOD Conjugates

Controlled endothelial delivery of SOD may alleviate abnormal local surplus of superoxide involved in ischemia-reperfusion, inflammation and other disease conditions. Targeting SOD to endothelial surface vs. intracellular compartments is desirable to prevent pathological effects of external vs. endo...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Shuvaev, Vladimir V., Muro, Silvia, Arguiri, Evguenia, Khoshnejad, Makan, Tliba, Samira, Christofidou-Solomidou, Melpo, Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916012/
https://ncbi.nlm.nih.gov/pubmed/27210108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.05.040
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