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Targeting Superoxide Dismutase to Endothelial Caveolae Profoundly Alleviates Inflammation Caused by Endotoxin
Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide anion in the ensuing endosomes. In endothelial cells, endosomal surplus of superoxide causes pro-inflammatory activation and TLR4 agonists act preferentially via caveolae-derived endosomes. To test the hypothe...
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| Vydáno v: | J Control Release |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5825285/ https://ncbi.nlm.nih.gov/pubmed/29292038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.12.025 |
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