Targeting Superoxide Dismutase to Endothelial Caveolae Profoundly Alleviates Inflammation Caused by Endotoxin

Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide anion in the ensuing endosomes. In endothelial cells, endosomal surplus of superoxide causes pro-inflammatory activation and TLR4 agonists act preferentially via caveolae-derived endosomes. To test the hypothe...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Shuvaev, Vladimir V., Kiseleva, Raisa Yu., Arguiri, Evguenia, Villa, Carlos H., Muro, Silvia, Christofidou-Solomidou, Melpo, Stan, Radu V., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825285/
https://ncbi.nlm.nih.gov/pubmed/29292038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.12.025
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