Targeting Superoxide Dismutase to Endothelial Caveolae Profoundly Alleviates Inflammation Caused by Endotoxin

Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide anion in the ensuing endosomes. In endothelial cells, endosomal surplus of superoxide causes pro-inflammatory activation and TLR4 agonists act preferentially via caveolae-derived endosomes. To test the hypothe...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Control Release
Egile Nagusiak: Shuvaev, Vladimir V., Kiseleva, Raisa Yu., Arguiri, Evguenia, Villa, Carlos H., Muro, Silvia, Christofidou-Solomidou, Melpo, Stan, Radu V., Muzykantov, Vladimir R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825285/
https://ncbi.nlm.nih.gov/pubmed/29292038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.12.025
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