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Catalase and Superoxide Dismutase Conjugated with Platelet-Endothelial Cell Adhesion Molecule Antibody Distinctly Alleviate Abnormal Endothelial Permeability Caused by Exogenous Reactive Oxygen Species and Vascular Endothelial Growth Factor

Reactive oxygen species (ROS) superoxide anion (O(2)(⨪)) and hydrogen peroxide (H(2)O(2)) produced by activated leukocytes and endothelial cells in sites of inflammation or ischemia cause endothelial barrier dysfunction that may lead to tissue edema. Antioxidant enzymes (AOEs) catalase and superoxid...

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Detalhes bibliográficos
Main Authors: Han, Jingyan, Shuvaev, Vladimir V., Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126647/
https://ncbi.nlm.nih.gov/pubmed/21474567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180620
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