An Aldol-based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

An aldol-based ‘build/couple/pair’ (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti- aldol reactions were performed to produce four stereoisomers of a Boc protected γ-amino acid....

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Hauptverfasser: Marcaurelle, Lisa A., Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R., Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D., Liu, Haibo, Lowe, Jason T., Marie, Jean-Charles, Mulrooney, Carol A., Pandya, Bhaumik A., Rowley, Ann, Ryba, Troy D., Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W., Akella, Lakshmi B., Ross, Nathan T., Zhang, Yan-Ling, Fass, Daniel M., Reis, Surya A., Zhao, Wen-Ning, Haggarty, Stephen J., Palmer, Michelle, Foley, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004530/
https://ncbi.nlm.nih.gov/pubmed/21067169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105119r
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