Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions

Orthogonally protected chiral β-hydroxy-γ-amino acids can be accessed in >100 g quantities from readily available starting materials and reagents in 3–4 steps. These chiral synthons contain two adjacent stereocenters along with suitably protected functional groups (O-TBS, N-Boc) for downstream re...

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Autori principali: Pandya, Bhaumik A., Dandapani, Sivaraman, Duvall, Jeremy R., Rowley, Ann, Mulrooney, Carol A., Ryba, Troy, Dombrowski, Michael, Harton, Marie, Young, Damian W., Marcaurelle, Lisa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150486/
https://ncbi.nlm.nih.gov/pubmed/21822337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.06.043
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