An Aldol-based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

An aldol-based ‘build/couple/pair’ (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build phase, a series of asymmetric syn- and anti- aldol reactions were performed to produce four stereoisomers of a Boc protected γ-amino acid....

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Marcaurelle, Lisa A., Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R., Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D., Liu, Haibo, Lowe, Jason T., Marie, Jean-Charles, Mulrooney, Carol A., Pandya, Bhaumik A., Rowley, Ann, Ryba, Troy D., Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W., Akella, Lakshmi B., Ross, Nathan T., Zhang, Yan-Ling, Fass, Daniel M., Reis, Surya A., Zhao, Wen-Ning, Haggarty, Stephen J., Palmer, Michelle, Foley, Michael A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004530/
https://ncbi.nlm.nih.gov/pubmed/21067169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105119r
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller