Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ accumulation. RARα signalling increases the expressio...

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Main Authors: Jarvis, C I, Goncalves, M B, Clarke, E, Dogruel, M, Kalindjian, S B, Thomas, S A, Maden, M, Corcoran, J P T
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2010
Assuntos:
Molecular and Developmental Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://ncbi.nlm.nih.gov/pubmed/20950278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07426.x
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