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Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ accumulation. RARα signalling increases the expressio...

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Autori principali: Jarvis, C I, Goncalves, M B, Clarke, E, Dogruel, M, Kalindjian, S B, Thomas, S A, Maden, M, Corcoran, J P T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://ncbi.nlm.nih.gov/pubmed/20950278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07426.x
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