Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ accumulation. RARα signalling increases the expressio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jarvis, C I, Goncalves, M B, Clarke, E, Dogruel, M, Kalindjian, S B, Thomas, S A, Maden, M, Corcoran, J P T
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Molecular and Developmental Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://ncbi.nlm.nih.gov/pubmed/20950278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07426.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados