Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain, neuronal cell loss and cognitive decline. We show here that retinoic acid receptor (RAR)α signalling in vitro can prevent both intracellular and extracellular Aβ accumulation. RARα signalling increases the expressio...

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Détails bibliographiques
Auteurs principaux: Jarvis, C I, Goncalves, M B, Clarke, E, Dogruel, M, Kalindjian, S B, Thomas, S A, Maden, M, Corcoran, J P T
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2010
Sujets:
Molecular and Developmental Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003897/
https://ncbi.nlm.nih.gov/pubmed/20950278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07426.x
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