Sirt1 Protects the Heart from Ischemia/Reperfusion

BACKGROUND: Sirt1, a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). METHODS AND RESULTS: Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardi...

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Main Authors: Hsu, Chiao-Po, Zhai, Peiyong, Yamamoto, Takanobu, Maejima, Yasuhiro, Matsushima, Shouji, Hariharan, Nirmala, Shao, Dan, Takagi, Hiromitsu, Oka, Shinichi, Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003297/
https://ncbi.nlm.nih.gov/pubmed/21060073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.958033
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