Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion

RATIONALE: The function of PKN, a stress-activated protein kinase, in the heart is poorly understood. OBJECTIVE: We investigated the functional role of PKN during myocardial ischemia/reperfusion (I/R). METHODS AND RESULTS: PKN is phosphorylated at Thr774 in hearts subjected to ischemia and reperfusi...

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Main Authors: Takagi, Hiromitsu, Hsu, Chiao-Po, Kajimoto, Katsuya, Shao, Dan, Yang, Yanfei, Maejima, Yasuhiro, Zhai, Peiyong, Yehia, Ghassan, Yamada, Chikaomi, Zablocki, Daniela, Sadoshima, Junichi
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081566/
https://ncbi.nlm.nih.gov/pubmed/20595653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.217554
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