Nicotinamide Mononucleotide, an Intermediate of NAD(+) Synthesis, Protects the Heart from Ischemia and Reperfusion

Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD(+)) synthesis, and Sirt1, an NAD(+)-dependent histone deacetylase, protect the heart against ischemia/reperfusion (I/R). It remains unknown whether Nampt mediates the protective effect...

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Detalhes bibliográficos
Main Authors: Yamamoto, Takanobu, Byun, Jaemin, Zhai, Peiyong, Ikeda, Yoshiyuki, Oka, Shinichi, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048236/
https://ncbi.nlm.nih.gov/pubmed/24905194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098972
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