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PPARα Association With Sirt1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart

BACKGROUND: Heart failure (HF) is accompanied by changes in cardiac metabolism characterized by reduced fatty acid (FA) utilization. However, the underlying mechanism and its causative involvement in the progression of HF are poorly understood. The peroxisome proliferator activated receptor-α (PPARα...

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Bibliographische Detailangaben
Veröffentlicht in:Circ Heart Fail
Hauptverfasser: Oka, Shin-ichi, Zhai, Peiyong, Yamamoto, Takanobu, Ikeda, Yoshiyuki, Byun, Jaemin, Hsu, Chiao-Po, Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651813/
https://ncbi.nlm.nih.gov/pubmed/26443578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002216
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