PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway

High energy production in mitochondria is essential for maintaining cardiac contraction in the heart. Genes regulating mitochondrial function are commonly downregulated during heart failure. Here we show that both PPARα and Sirt1 are upregulated by pressure overload in the heart. Haploinsufficiency...

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Detalhes bibliográficos
Main Authors: Oka, Shin-ichi, Alcendor, Ralph, Zhai, Peiyong, Park, Ji Yeon, Shao, Dan, Cho, Jaeyeaon, Yamamoto, Takanobu, Tian, Bin, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217210/
https://ncbi.nlm.nih.gov/pubmed/22055503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.10.001
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