DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

DNA damage can induce a tumor suppressive response termed cellular senescence. Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other proteins and harbor persistent nuclear foci that contain DNA damage response (DDR) proteins. To understand how persistent damage...

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Main Authors: Rodier, Francis, Muñoz, Denise P., Teachenor, Robert, Chu, Victoria, Le, Oanh, Bhaumik, Dipa, Coppé, Jean-Philippe, Campeau, Eric, Beauséjour, Christian M., Kim, Sahn-Ho, Davalos, Albert R., Campisi, Judith
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001408/
https://ncbi.nlm.nih.gov/pubmed/21118958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.071340
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