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Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

Inflammation underlies most age-related diseases, including cancer, but the etiology is poorly understood. One proposed factor is the presence of senescent cells, which increase with age. The senescence response arrests the proliferation of potentially oncogenic cells, and most senescent cells secre...

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Hlavní autoři: Orjalo, Arturo V., Bhaumik, Dipa, Gengler, Bridget K., Scott, Gary K., Campisi, Judith
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761322/
https://ncbi.nlm.nih.gov/pubmed/19805069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905299106
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