DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

DNA damage can induce a tumor suppressive response termed cellular senescence. Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other proteins and harbor persistent nuclear foci that contain DNA damage response (DDR) proteins. To understand how persistent damage...

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Bibliographische Detailangaben
Hauptverfasser: Rodier, Francis, Muñoz, Denise P., Teachenor, Robert, Chu, Victoria, Le, Oanh, Bhaumik, Dipa, Coppé, Jean-Philippe, Campeau, Eric, Beauséjour, Christian M., Kim, Sahn-Ho, Davalos, Albert R., Campisi, Judith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001408/
https://ncbi.nlm.nih.gov/pubmed/21118958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.071340
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