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Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells1. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments2. The pathways regulating this secretion are unknown. We show that damaged human cells develop persistent chromatin l...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743561/ https://ncbi.nlm.nih.gov/pubmed/19597488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1909 |
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