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Ligand- and Subunit-specific Conformational Changes in the Ligand-binding Domain and the TM2-TM3 Linker of α1 β2 γ2 GABA(A) Receptors
Cys-loop receptor ligand binding sites are located at subunit interfaces where they are lined by loops A–C from one subunit and loops D–F from the adjacent subunit. Agonist binding induces large conformational changes in loops C and F. However, it is controversial as to whether these conformational...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001017/ https://ncbi.nlm.nih.gov/pubmed/20937799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161513 |
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