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Agonist-Specific Conformational Changes in the α1-γ2 Subunit Interface of the GABA(A) Receptor
The GABA(A) receptor undergoes conformational changes upon the binding of agonist that lead to the opening of the channel gate and a flow of small anions across the cell membrane. Besides the transmitter GABA, allosteric ligands such as the general anesthetics pentobarbital and etomidate can activat...
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| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400839/ https://ncbi.nlm.nih.gov/pubmed/22572883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.077875 |
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