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Agonist-Specific Conformational Changes in the α1-γ2 Subunit Interface of the GABA(A) Receptor

The GABA(A) receptor undergoes conformational changes upon the binding of agonist that lead to the opening of the channel gate and a flow of small anions across the cell membrane. Besides the transmitter GABA, allosteric ligands such as the general anesthetics pentobarbital and etomidate can activat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Eaton, Megan M., Lim, You Bin, Bracamontes, John, Steinbach, Joe Henry, Akk, Gustav
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400839/
https://ncbi.nlm.nih.gov/pubmed/22572883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.077875
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