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Ligand-specific Conformational Changes in the α1 Glycine Receptor Ligand-binding Domain

Understanding the activation mechanism of Cys loop ion channel receptors is key to understanding their physiological and pharmacological properties under normal and pathological conditions. The ligand-binding domains of these receptors comprise inner and outer β-sheets and structural studies indicat...

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Autores principales: Pless, Stephan A., Lynch, Joseph W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708881/
https://ncbi.nlm.nih.gov/pubmed/19286654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809343200
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