Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain

Molecular dynamics simulations of a homology model of the ligand binding domain of the α7 nicotinic receptor are conducted with a range of bound ligands to induce different conformational states. Four simulations of 15 ns each are run with no ligand, antagonist d-tubocurarine (dTC), agonist acetylch...

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Päätekijät: Henchman, Richard H., Wang, Hai-Long, Sine, Steven M., Taylor, Palmer, McCammon, J. Andrew
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Biophysical Society 2005
Aiheet:
Channels, Receptors, and Electrical Signaling
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305353/
https://ncbi.nlm.nih.gov/pubmed/15665135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.053934
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