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Ligand-Induced Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain
Molecular dynamics simulations of a homology model of the ligand binding domain of the α7 nicotinic receptor are conducted with a range of bound ligands to induce different conformational states. Four simulations of 15 ns each are run with no ligand, antagonist d-tubocurarine (dTC), agonist acetylch...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Biophysical Society
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1305353/ https://ncbi.nlm.nih.gov/pubmed/15665135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.053934 |
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