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Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors
Proteasomes degrade most proteins in mammalian cells and are established targets of anti-cancer drugs. The majority of proteasome inhibitors are composed of short peptides with an electrophilic functionality (pharmacophore) at the C terminus. All eukaryotic proteasomes have three types of active sit...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000995/ https://ncbi.nlm.nih.gov/pubmed/20937826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160606 |
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