Selective inhibitor of proteasome’s caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

Proteasomes degrade most proteins in mammalian cells and are established targets of anti-cancer drugs. All eukaryotic proteasomes have three types of active sites: chymotrypsin-like, trypsin-like, and caspase-like. Chymotrypsin-like sites are the most important in protein degradation and are the pri...

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Detalhes bibliográficos
Main Authors: Britton, Matthew, Lucas, Marcella M., Downey, Sondra L., Screen, Michael, Pletnev, Alexandre A., Verdoes, Martijn, Tokhunts, Robert A., Amir, Omar, Goddard, Ayrton L, Pelphrey, Philip M., Wright, Dennis L., Overkleeft, Herman S., Kisselev, Alexei F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807417/
https://ncbi.nlm.nih.gov/pubmed/20064438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.11.015
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