Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

The clinical efficacy of opiates for pain control is severely limited by analgesic tolerance and hyperalgesia. Herein we show that chronic morphine upregulates both the sphingolipid ceramide in spinal astrocytes and microglia, but not neurons, and spinal sphingosine-1-phosphate (S1P), the end-produc...

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Autori principali: Muscoli, Carolina, Doyle, Tim, Dagostino, Concetta, Bryant, Leesa, Chen, Zhoumou, Watkins, Linda R., Ryerse, Jan, Bieberich, Erhard, Neumman, William, Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000610/
https://ncbi.nlm.nih.gov/pubmed/21084596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2391-10.2010
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