Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids

The clinical efficacy of opiates for pain control is severely limited by analgesic tolerance and hyperalgesia. Herein we show that chronic morphine upregulates both the sphingolipid ceramide in spinal astrocytes and microglia, but not neurons, and spinal sphingosine-1-phosphate (S1P), the end-produc...

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Hauptverfasser: Muscoli, Carolina, Doyle, Tim, Dagostino, Concetta, Bryant, Leesa, Chen, Zhoumou, Watkins, Linda R., Ryerse, Jan, Bieberich, Erhard, Neumman, William, Salvemini, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000610/
https://ncbi.nlm.nih.gov/pubmed/21084596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2391-10.2010
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