Opioid-Induced Glial Activation: Mechanisms of Activation and Implications for Opioid Analgesia, Dependence, and Reward

This review will introduce the concept of toll-like receptor (TLR)–mediated glial activation as central to all of the following: neuropathic pain, compromised acute opioid analgesia, and unwanted opioid side effects (tolerance, dependence, and reward). Attenuation of glial activation has previously...

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Detalhes bibliográficos
Publicado no:ScientificWorldJournal
Main Authors: Hutchinson, Mark R., Bland, Sondra T., Johnson, Kirk W., Rice, Kenner C., Maier, Steven F., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: TheScientificWorldJOURNAL 2007
Assuntos:
Mini-Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901235/
https://ncbi.nlm.nih.gov/pubmed/17982582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/tsw.2007.230
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